Department of Biotechnology (Plant)

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ZHANG Mingzhe

Date:2021-01-07 15:42:53     Times:



Mingzhe Zhang





Associate Professor Specializing in Natural Product Chemistry and Chemical biology


The research focuses on the biosynthesis and metabolic regulation of bioactive secondary metabolites in plants or microorganisms, as well as their applications in agriculture, medicine, food and other fields, and also explores the natural functions of secondary metabolites in natural environment.

we currently focus on genome-wide functional analysis of virulence-associated factors in Botrytis cinerea , the gray mold fungus that infects over 1400 plant species and annually causes enormous economic losses worldwide, and dissection of molecular and/or biochemical mechanisms of the pathogenicity-associated factors that regulate the pathogen development and host infection as well as host immune responses

Academic career

B.S., 2002 Quartermaster University of Chinese PLA

M.D., 2007 Jilin University:  

Ph.D., 2020 Jilin University:  


Work address

5333 Xi’an Road, Changchun City,

Jilin Province, China  





1.Zhang MZ*, Sun CH, Liu Y, Feng HQ, Chang HW, Cao SN, Li GH, Yang S, Hou J, Zhu-Salzman K, Zhang H, Qin QM*, Transcriptome analysis and functional validation reveal a novel gene BcCGF1 that enhances fungal virulence by promoting infection-related development and host penetration, Molecular Plant Pathology, 2020,00:1–20. DOI: 10.1111/mpp.12934 (IF5-yr: 4.96)

2.Hou J*, Feng HQ, Chang HW, Liu Y, Li GH, Yang S, Sun CH, Zhang MZ, Yuan Y, Sun J, Zhang H, Qin QM*, The H3K4 demethylase Jar1 orchestrates ROS production and expression of pathogenesis-related genes to facilitate Botrytis cinerea virulence, New Phytologist, 2020, 225: 930-947. (IF5-yr: 8.67)

3.Wang HY*, Zhang MZ*, Han X*, Cong J*, Wang SQ, He SL, Wei DS, Zhang YB, Qin JC and Diego A. Sampeitro, Insecticidal and repellent efficacy of the essential oil from Lobularia maritima and trans-3-pentenenitrile against insect pests of stored grains, International Journal of Food Properties, 2020, 23:1, 1125-1135, DOI:10.1080/10942912.2020.1778723

4.Wang SQ*, He SL*, Zhang MZ*, Zhang YX, Wang QY Zhang CY, Liu TY, Liu B, Han JY*, Qin JC*, Sampietro Diego A, Chemical composition and allelopathic potential of essential oils from Eupatorium maculatum onLolium perenne L. and Echinochloa crusgalli L. Allelopathy J. 2020, DOI:10.26651/allelo.j/2020-49-1-1253

5.Yang SX*, Song CG*, Kuang Y, Liu B, Zhang YX, Zhang MZ, Zhang CY, Ding G* and Qin JC*, Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada, Molecules, 2020, 25, 1222; doi:10.3390/molecules25051222

6.He SL*, Wang DC*, Zhang YM*, Yang SX, Li X, Wei DS, Zhang MZ, Qin JC*, Chemical Components and Biological Activities of the Essential Oil from Traditional Medicinal Food, Euryale ferox Salisb., Seeds, Journal of Essential Oil Bearing Plants, 2019, DOI: 10.1080/0972060X.2019.1595165

7.Song CG*, L J, Wang HY, L X, L B, Zhang MZ, Shang XH, L H, Gao JM* and Qin JC*, New Derivatives from Microbial Transformation of ent-Kaur-16-en-19-oic Acid by Cunninghamella echinulate. Chem Biodivers, 2020, DOI: 10.1002/cbdv.202000178

8.Song CG*, D G, Wu G, Yang J, Zhang MZ, Wang HY, Wei DS, Qin JC and Guo LP, Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum, Chem. Biodivers, 2020, DOI: 10.1002/cbdv.201900744

9.Wei Y*, Li LH*, Hu WJ, Ju HY, Zhang MZ, Qin QM, Zhang SH, Li GH, Suppression of Rice Blast by Bacterial Strains Isolatedfrom Cultivated Soda Saline-Sodic Soils, Int. J. Environ. Res, 2020, 17, 5248; doi:10.3390/ijerph17145248

10.Liu Y*, Liu JK, Li GH, Zhang MZ, Zhang YY, Wang YY, Hou J, Yang S, Sun J, Qin QM*, A novel Botrytis cinerea-specific gene BcHBF1 enhances virulence of the grey mould fungus via promoting host penetration and invasive hyphal development, Molecular Plant Pathology, 2019, 20(5): 731-747. (IF5-yr: 4.96)

11.Liu JK*, Chang HW, Liu Y, Qin YH, Zhang MZ, Cao SN, Li LT, Li GH, Qin QM*, The key gluconeogenic gene PCK1 is crucial for virulence of Botrytis cinerea via initiating its conidial germination and host penetration. Environmental Microbiology, 2018, 20(5): 1794-1814. (IF5-yr: 5.965)

12.Cao SN*, Yuan, Y, Qin YH, Zhang MZ, de Figueiredo P, Li GH*, and Qin QM*; The pre-rRNA processing factor Nop53 regulates fungal development and pathogenesis via mediating production of reactive oxygen species. Environmental Microbiology, 2018, 20(4): 1531-1549. (IF5-yr: 5.965)

13.Yang SX, Liu B, Tang M, Yang J, , Kuang Y, Zhang MZ, Zhang CY, Wang CY, Qin, JC*, Guo LP*,2019, Extraction of flavonoids from Cyclocarya paliurus (Juglandaceae) Iljinskaja leaves using  ethanol/salt aqueous two-phase system coupled with ultrasonic. Journal of Food Processing and Preservation. Doi:10.1111/jfpp.14469.

14.Aseem Pandey, Furong Lin, Xuehuan Feng, Allison Rice-Ficht, Hui-Qiang Feng, Thomas A. Ficht, Ana L. Cabello, Ming-Zhe Zhang, Luciana F. da Costa, Takao Iwawaki, Paul de Figueiredo and Qing-Ming Qin* 2018, Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2018.00103

15.Wang DC*. Zhang YM, Li, X, Pan HY, Chang, M. Zheng, T. Sun JZ. Qiu DR. Zhang MZ. Wei DS, Qin, JC, Potential allelopathic azaphilones produced by the endophytic Chaetomium globosum TY1 inhabited in Ginkgo biloba using the one strain-many compounds method. 2017, Nat Prod Res. DOI: 10.1080/14786419.2016.1217208

16.Qiu DR*, Wang DC, Yang SX, Zhang YM, Wei DS, Zhang MZ, Sun JZ, Cong J, Guo J, He SL, Qin, JC, 2016, Chemical constituents from the fruits of Rhus typhina L. and their chemotaxonomic significance. Biochemical Systematics and Ecology, 2016, DOI: 69, 261-265, doi:10.1016/j.bse.2016.10.011.

17.Qiu DR*, Wang DC, I.M. Chung, Zhang MZ, H.Cheng, Wei DS, Qin JC, Yang SX, Allelopathic effects of essential oil of Hosta ventricosa flowers on seed germination and seedling growth of crops. 2015, Allelopathy J , DOI: 36, 103-108


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